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Agonist maintenance therapy is the most effective known treatment and has been shown to reduce the risk of new HCV infection.[35] Data on the use of DAAs and medications for opioid use disorder (MOUD) indicate comparable SVR rates when comparing persons on MOUD with those who do not use drugs.[22,23,26,27,29,31] Injectable extended-release naltrexone is also approved for opioid dependence, although access can be challenging and uptake can be limited
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