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In the presence of high concentrations of polyamines the ribosome frameshifting occurs resulting in the synthesis of functional antizyme 1 which comprises amino acids from both ORF1 and ORF2

Agency feedback can mean more data collection or further analysis, which can shift this timeline

Publicly available data used to verify status of Florida, Kansas, Minnesota, and Mississippi (these states did not respond to the 2025 survey or this survey question)

Enterococcus mundtii ST4SA and Lactobacillus plantarum 423 excludes Listeria monocytogenes from the GIT, as shown by bioluminescent studies in mice

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