Key TakeawaysMenopause hormone therapy appears to boost the effectiveness of tirzepatide (Zepbound)Women lost more weight with the combo, and more women lost at least 20% of body weightThe findings reflect earlier results with semaglutide (Wegovy).MONDAY, July 14, 2025 (HealthDay News) Good news for women of a certain age: Hormone replacement therapy for menopause appears to boost the effectiveness of GLP-1 weight loss drugs like Wegovy and Zepbound, a new study says.Women using tirzepatide (Zepbound) lost more weight if they also were taking hormone therapy 17% of body weight lost versus 14% after a median 18 months, researchers reported Saturday at the Endocrine Societys annual meeting in San Francisco.Further, more women taking Zepbound and hormone therapy achieved at least 20% total body weight loss, with 45% meeting this goal compared to 18% of those not on hormone therapy.These data are the first to show the combined use of tirzepatide and menopause hormone therapy significantly increases treatment effectiveness in postmenopausal women, presenting investigator Dr
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Shibahara, S., Sato, M., Muller, R
Hazard ratios with 95% confidence intervals (CIs) were obtained using Cox proportional hazards models, adjusted for possible confounders, and various sensitivity analyses were also performed
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