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Spellberg B, Guidos R, Gilbert D, Bradley J, Boucher HW, Scheld WM, et al
The 2018 NASEM report concludes that there is not enough sound evidence to say for sure that e-cigarettes are an effective cessation strategy
Additional opportunities exist in the synthetic and tobacco-free nicotine segment, where producers who invest in fermentation-based or chemical synthesis routes can differentiate their products on regulatory positioning and supply chain traceability, potentially commanding price premiums of 30-50% above plant-derived equivalents in premium consumer and pharmaceutical markets
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