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An illuminating illustration of different IBPs having different metabolic needs and altering host cell metabolism to meet their (the IBPs) metabolic needs is as follows: Listeria monocytogenes was shown to activate metabolic pathways related to energy production and cell growth in bone marrow derived macrophages (BMDMs) after infecting them, which allowed for their growth in the immune cell

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In vitro work can either establish a foundation upon which in vivo work with animals and humans can be based or it can provide a means to study results obtained in vivo in more depth