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According to the study, UA had a direct proinflammatory effect on human macrophages manifested by increased macrophage phagocytic activity, the production of TNF-alpha and toll-like receptor 4 (TLR4), and downregulated the urate anion transporter 1 expression. [ Uric acid is believed to contribute to the antioxidant potential in plasma but within the cell it is rather pro-oxidant

Metabolism of Oltipraz Metabolism of OPZ results in the production of a minor oxo analog (2), and the major dimethylated pyrrolopyrazine (3) through the biological methylation of the intermediate pyrrolopyrazine thione (4).

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