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The targeting cargo of mitophagy to autophagosomes is recognized by a body of ubiquitin-binding autophagic adaptors (eg, p62/SQSTM1/sequestosome-1), which connect the ubiquitin system and the autophagic mechanism, promoting the binding of autophagic substrates and the small ubiquitin-like modifiers that belong to the autophagy-related 8/LC3 family located on the membrane of autophagosomes

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