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Combinational blockade of MET and PD-L1 improves pancreatic cancer imm unotherapeutic efficacy

The lack of studies means dosing protocols are speculative, side effect profiles unknown, and risks potentially severe - particularly gastroparesis from combined extreme gastric slowing

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The discovery of the iron-dependent lethal compound ironomycin that localizes to lysosomes [44] suggests that additional studies concerning the role of lysosomes in ferroptosis may be needed to evaluate the relationships between lysosomal lipid ROS and cell death