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Histone Kla activates genes linked to energy metabolism, while lactate directly modifies metabolic enzymes, affecting their degradation, stability, and interactions and eventually leading to metabolic reprogramming

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It is also possible that HPA sensitivity rather than HPA axis dysfunction exists in patients (63)

In line with its important functions in the maintenance of cellular redox homeostasis, GSH also participates in the detoxification of toxic metals/metalloids