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Joseph Lambson, director of the New Mexico Poison and Drug Information Center, detailed what happened to three people who called the Utah Poison Control hotline, which saw calls related to semaglutide nearly quadruple between 2021 and 2022

[40] The theoretical risk of immune system stimulation could potentially worsen disease activity or reduce the effectiveness of immunosuppressive medications

The more serious concern is a black box FDA warning around suicidal thoughts linked to the bupropion ingredient, particularly in younger adults under 24

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2025;doi:10.1001/jamaophthalmol.2025.0349