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TMP significantly reduces the expression levels of pro-inflammatory factors TNF-, IL-1, and IL-6 by inhibiting signaling pathways such as NF-B, while simultaneously upregulating the synthesis of tight junction proteins Zonula Occludens-1 (ZO-1) and Occludin, thereby maintaining the structural integrity of the intestinal epithelium ( 2 O 2 ) in lineage-specified progenitor (LSK) cells, hematopoietic progenitor cells (HPC), hematopoietic stem cells (HSC), and multipotent progenitor cells (MPP) (Zhu et al., 2019)

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doi:10.1056/NEJMoa1811744 Pernicova I, Korbonits M

The molecular regulation of Janus kinase (JAK) activation