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In a statement, FDA spokesman Jim McKinney said the plan would be among the most impactful population-level actions in the history of U.S

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In relation to region, results from our adjusted models indicate a protective effect of living in rural areas such that teenagers whose caregivers smoked were more likely to use e-cigarettes but those in rural areas were significantly less likely than those in urban areas (aORs ranging from 0.87 to 0.89)