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Since randomized trials and prospective cohort designs on this topic are not practical given the ethical issues and the need for a large study population with extended follow-up, there is a need for well-designed retrospective studies despite the inherent limitations from recall bias and unmeasured confounding factors

In fact, a report by a committee of the FDA concluded that if menthol cigarettes had been removed from the marketplace in 2010, then (a) by 2020, roughly 17,000 premature deaths would have been avoided and about 2.3 million people would not have started smoking

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