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To date, there are no studies showing the efficacy and safety of augmentation therapy in systemic vasculitis but there are case reports on its successful use in cutaneous vasculitis in individuals with A1ATD, particularly with PiZZ phenotype ( 2.3.2.4 Fibromyalgia Fibromyalgia (FM) is a chronic disorder characterized by widespread musculoskeletal pain, fatigue, sleep disorders, and heightened sensitivity to pressure or touch

50% for vitamin C and 40% for tretinoin), without the irritation or photosensitivity that retinoids commonly cause

You can have arguments all you want with research