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Alkhouri N, Herring R, Kabler H et al (2022) Safety and efficacy of combination therapy with semaglutide, cilofexor and firsocostat in patients with non-alcoholic steatohepatitis: A randomised, open-label phase II trial

A 10 nmol/kg dose level of semaglutide was chosen depending on a previous study demonstrating its anti-inflammatory effects in a rat model of stroke (Yang et al

10.1016/j.bbrc.2020.11.109 121 XieL.YuanY.XuS.LuS.GuJ.WangY.et al (2022)

Tirzepatide, a dual GIP/GLP-1 receptor co-agonist, may induce a specific microbial footprint that differs from pure GLP-1 agonism, as GIP signaling independently participates in lipid handling and mucosal immune regulation, potentially modifying the nutrient-delivery profile to the gut (54)

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