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Studies in 293 subjects with biopsy-confirmed MASH showed improved MASH without worsening fibrosis in 47%, 62%, and 43% of participants receiving 2.4 mg, 4.8 mg, and 6.0 mg doses, respectively, versus 14% with placebo [103,108]

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Abstract This review provides a comprehensive examination of the clinical pharmacological mechanisms and broad therapeutic applications of glucagon-like peptide-1 receptor agonists (GLP-1RAs) and dual receptor agonists targeting both glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) receptors