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dose monitoring is advised

Additionally, metabolic adaptations that occurred during weight lossincluding decreased energy expenditure and hormonal changes that favor weight regainbecome more apparent once the medication's counterbalancing effects are removed

Under this perspective, as reported in a systematic analysis for the Global Burden of Disease Study 2021 [1, 2], the age-standardized rates of deaths per 100,000 individuals attributed to 37 unique conditions affecting the nervous system that now include neurodevelopmental disorders, late-life neurodegeneration, and emergent conditions such as cognitive impairment following coronavirus disease 2019 (COVID-19), has decreased by 33.6% from 1990 to 2021

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4-Hydroxy-trans-2-nonenal in the regulation of anti-oxidative and pro-inflammatory signaling pathways