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In an experimental study conducted by Thimmulappa et al., 2006, the authors reported proinflammatory stimulation with a rise of the level of TNF- and the induction of sepsis in mice with a deficiency of NFR-2 [27]

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Secondly, significant weight loss and the resultant change in the inflammatory phenotype of obese adipose tissue would reduce the release into the circulation of key pro-fibrotic pro-inflammatory cytokines/adipokines such as TNF-, IL-6, leptin [31], visfatin and resistin, and increase levels of anti-fibrotic adipokines such as adiponectin [32]

2020 Nov 24;117(47):29959-29967