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However, the precise mechanisms underlying these processes remain poorly understood, and the therapeutic potential of targeting ROS homeostasis regulation for disease intervention has not been systematically elucidated

blockade of the methionine cycle

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Critical challenges in catalytic efficacy and biosafety The primary challenge lies in the gap of catalytic efficacy: despite the continuous improvement of design strategies, the catalytic efficiency and substrate specificity of most nanozymes are still far inferior to those of natural enzymes

GeroScience 41:7787