Cardiac disorder: chest pain, dyspnea, palpitations Gastrointestinal disorders: abdominal pain, nausea, vomiting, diarrhea General disorders and administration site conditions: chest pain, fatigue, pain, malaise, injection site pain or erythema, feeling abnormal, pyrexia, condition aggravated, asthenia Immune system disorders: hypersensitivity reactions, including pruritus, rash, urticaria, erythema Injury, poisoning, and procedural complications: injury Investigations: weight decreased Musculoskeletal and connective tissue disorders: pain in extremity, arthralgia, back pain, muscle spasm Nervous system disorders: headache, migraine, dizziness, hypoesthesia, paresthesia Psychiatric disorders: depression, insomnia, anxiety Reproductive system and breast disorders: metrorrhagia, menorrhagia, hot flush, vaginal hemorrhage Respiratory, thoracic, and mediastinal disorders: nasopharyngitis, cough Sleep disorders and disturbances: somnolence Vascular disorders: deep vein thrombosis, pulmonary embolism Consult the labeling of concurrently used drugs to obtain further information about interactions with hormonal contraceptives or the potential for enzyme alterations
The harmful effects of smoking had just started to become public knowledge at that time
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Other possible mechanisms may include cervical mucus changes that inhibit sperm penetration and endometrial changes that reduce the likelihood of implantation
The FDA intends to finalize a guidance document that would commence enforcement to require that all flavors, other than tobacco flavor, be removed from the market
