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At the time, tobacco farmers could only sell their crop to the Spanish Crown, at prices determined by the Crown, not the market

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To match the population, 400 middle schools and 400 high schools were chosen for sample allocation each year using proportional sampling

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Given the immunosuppressive features of cannabis smoke on lung macrophages, a similar response could occur, although more research is needed to understand the impact of cannabis smoke and cannabinoids on macrophage efferocytosis and whether such changes are beneficial or detrimental