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Nature 225 , 379380 (1970)

Physiology-Cell Physiology 281 (6), C1757C1768

Most of the data come from animal studies or small, open label reports

Research describes the glutathione system as an important component of cardiovascular antioxidant defense, although its role as a routine clinical cardiovascular biomarker is still being defined

Therefore, the precise mechanisms through which lipoxygenases contribute to ferroptosis, particularly in GPX4 inhibition contexts, require further investigation ( 3.2.4 Therapeutic targets and experimental evidence Lipid peroxidation not only affects biological membrane fluidity and membrane protein function, impairing cellular activity, but its products also form reactive aldehyde end products, including 4-hydroxynonenal (4-HNE) and MDA