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The mechanisms of action and efficacy of herbs remain inconclusive [8, 151,152,153]

Moreover, we have shown that targeting the xc system can overcome this effect (see overview in Figure 6), adding to the evidence that targeting xc enhances the efficacy of anti-cancer agents in leukemias9 and in several solid cancer models.3835 MSC viability was unaffected by PTL and targeting xc, so damage to this important element of the BM environment4039 should be minimal

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