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(2020) 371:m4269

Pharmacologic BRAF inhibition with vemurafenib decreased lactate production, reduced H4K12la occupancy at cell-cycle loci such as CDK1 and CCNE1, and blocked tumor cell growth, whereas exogenous lactate or p300 activation restored the mark and partially rescued proliferation

zooepidemicus , E

This combination is designed to provide a dual-acting research model for evaluating growth hormone release, peptide synergy, and downstream biological signaling