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However, due to the lack of targeted experimental studies, more research is needed to explore the combined mechanisms of ETS and nutrients supplement exposure during pregnancy leading to childhood obesity in the future

Another ligand for RAGE is the nuclear protein high-mobility group box-1 (HMGB1), which is normally buried deep within the nucleus and can be released into the extracellular space by passive diffusion from necrotic cells or by active secretion from activated macrophages/monocytes

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