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Furthermore, the chronic state of hyperglycemia worsens the continuous decline of beta-cell function

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Of particular note are the weaker interactions between ICL2 with the N and hns1/S1 region of G s and between H8 and G , in addition to differences in interactions between ICL3/TM6 with the G s 5 helix within the exendin-P5 and oxyntomodulin-bound complexes, compared to GLP-1

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