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Consequently, FIN56 inhibits Sec integration into the catalytic subunit of GPX4, reducing its antioxidant capacity ( 4.2 Non-enzymatic pathway of ferroptosis 4.2.1 Iron homeostasis Iron is crucial for living organisms, and its deficiency can cause health issues

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Clinical trials have demonstrated that oral atorvastatin can improve the quality of life and reduce eye lesions in active TAO patients with hypercholesterolemia compared to intravenous corticosteroids (121)

The histidine imidazole ring, glycine amino groups, and deprotonated amide nitrogens coordinate the copper ion, creating a stable chelation complex