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The number on the scale may change but the internal programming that shaped the old weight set point often stays the same
In the third sensitivity analysis, excluding patients using other types of glucagon-like peptide-1 receptor agonists, the use of once-weekly semaglutide still independently predicted a higher risk of upcoming NAION (multivariable adjusted HR 234, 95% CI 154 357), compared to non-semaglutide users in a multivariable model adjusted as in the first sensitivity analysis
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The drug is currently progressing through Phase 3 clinical trials under the TRIUMPH programme, which is evaluating its efficacy and safety across a range of populations