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Public Health 111 , 16611672 (2021)
Its Very Expensive to Smoke The NHS tell people that it costs 3,000 a year to smoke
It's actually working exactly as designed, but it's responding to the wrong signal
The expressions of two key glycolytic enzymes hexokinase II (HK-II) and pyruvate dehydrogenase kinase 2 (PKM2) are mediated by transcription factors hypoxia-inducible factor 1 (HIF-1) and tumor suppressor gene p53, respectively, and dysregulation of these two transcription factors by cigarette smoke [34, 35] represents a possible explanation for the enhanced glycolysis in CSE-treated NSCLC cells
Same as above, except this time, they wont catch the flint because the grooves that do the catching are clogged usually with flint-dust from hundreds of previous strikings
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