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Pabelick, [email protected] This article was submitted to Integrative Physiology, a section of the journal Frontiers in Physiology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

(1-3) Careful consideration of individual patient parameters facilitates the creation of a risk profile that optimally supports the maintenance of good health and patient quality of life

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Diagnosis [edit] Increased nicotine or cotinine (the nicotine metabolite) is detected in urine or blood, or serum nicotine concentrations increase