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Mendelian randomization (MR) is a genetic epidemiological approach that utilizes single nucleotide polymorphisms (SNPs) randomized during meiosis as instrumental variables to infer the effect of an exposure on an outcome

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To support his claim, Ipsen draws upon the character Bruno Cortona from Dino Risis Il sorpasso ( The Easy Life , 1962), in which the outgoing smoker played by Vittorio Gassmann lives a carefree life and chastises the introverted Roberto for his non-smoking ways (149-150)