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As a result: Cortisol levels remain elevated Inflammation increases Blood pressure rises Immune function weakens Sleep quality declines Over time, this constant stress state contributes to cardiovascular disease, metabolic disorders, mental health challenges, and reduced lifespan

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Diagnosis of IBS by the Rome IV criteria IBS was diagnosed if the patient reported recurrent abdominal pain occurring on average at least one day per week in the last three months that was associated with two or more of the following criteria: abdominal pain related to defecation

It also turns on a twist to the show's narrative formula and premise, while being true to the show's spirit

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