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Absence of large-scale clinical trials, delaying regulatory approvals and mainstream adoption (McGleenon et al., 1999)

However, the clinical benefit of this modality has still been limited due to several defects such as adverse events, acquired drug resistance, tumor recurrence, and lack of validated biomarkers, which impel further research on mechanisms of tumor angiogenesis, the development of multiple drugs and the combination therapy to figure out how to improve the therapeutic efficacy

Int J Pharm 626, 122152.CrossRefGoogle ScholarPubMed Karthik, Y, Ishwara Kalyani, M, Krishnappa, S, et al