Consider initial therapy at this stage when blood glucose 300 to 350 mg/dL (16.7 to 19.4 mmol/L) and/or HbA1C 10%-12% (86 to 108 mmol/mol), especially if the patient is symptomatic or if catabolic features (eg, weight loss, ketosis) are present, in which case basal insulin + mealtime insulin is the preferred initial regimen
H., Lee, M
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free radical scavenging activity, suppression of intracellular calcium influx, blockage of Na + channel activation, reduction of intracranial pressure, tissue edema, and inflammation (Santos et al., 2003)