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Berberine activates AMPK through a different mechanism than MOTS-c (via inhibition of complex I in mitochondria), so concurrent use may create additive rather than synergistic AMPK activationhigher risk of hypoglycemia without proportional metabolic benefit

Intraperitoneal glucose tolerance tests (IPGTTs) were then performed at 0, 4, and 8 h after 2.4 nmol kg 1 agonist administration, revealing a strikingly persistent anti-hyperglycemic effect of exendin-phe1 vs

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It is also classified as a growth hormone (GH) secretagogue due to its ability to increase the secretion of GH and insulin growth-factor 1 (IGF-1) in the body