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Additionally, intestinal epithelial cells can import intact GSH from the lumen via specific plasma membrane transporters ( FIGURE 3 FIGURE 4 Glutathione cellular distribution Glutathione is found in almost all cellular compartments, including the nucleus (54, 6468) (Figures 2, 4)

Therefore, the intracellular levels of GSH are regulated by the negative feedback of GSH itself on the GCL enzyme (5557) and by the availability of the amino acid L-cysteine (58)

By neutralising these free radicals, glutathione helps protect cells from damage, slowing down ageing and reducing the risk of chronic diseases such as heart disease, diabetes, and neurodegenerative disorders

Conversely, suppose the glutathione production process (or the trans-sulfuration pathway) is not functioning correctly