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In rabbits, the reported IV effective dose was 25 mcg/kg while the subcutaneous dose was 1 mg/kg a 40-fold difference

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One patient was reported to have learning disability with dyslexia and was also thought to be mentally retarded [5], and another had delayed psychomotor development and progressive sensory neuropathy of lower extremities, ataxia, hyperreflexia, dysarthria, and a peculiar gait suggestive of spinocerebellar degeneration [2]

However, in vivo studies yielded conflicting results, with eosinophils appearing to play protective (da Silva Marques et al, 2021

In Novo Nordisk clinical trials it is being tested in combination with semaglutide (CagriSema) in Phase 3 obesity trials