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Lung cancer death rates by smoking status: comparison of the Three-Prefecture Cohort study in Japan to the Cancer Prevention Study II in the USA

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Disturbance in proliferation together with weakened migration can lead to decreased availability of MSCs in the healing tissue, which could potentiate the detrimental effect of smoking in vivo

In addition to stimulating the increase of eosinophils, neutrophils, mast cells, and macrophages (red box), CS can also combine with RAGE to further stimulate the expression of IL-33, gradually aggravating airway remodeling