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A new generation of GLP-1 drugs is already emerging, including treatments designed to reduce side effects such as muscle loss

82 Glutamate Glutamate is the main excitatory neurotransmitter in the central nervous system (CNS) 83 and can be released by neurons through exocytosis, which in turn activates extracellular N-methyl-D-aspartate receptors (eNMDARs) in neurons, leading to synaptic loss

Among these, leptin, resistin, lactone, adiponectin, chemerin, retinol binding protein-4(RBP-4), and lipoprotein-associated phospholipase A2(Lp-PLA2) emerge as key mediators

This level of dosing flexibility is impossible with fixed-dose pens

Healthy rats treated with retatrutide showed increased BDNF and CREB mRNA expression levels