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In a study of 20 tobacco cigarette smokers who substituted tobacco cigarettes with e-cigarettes for two weeks all the tobacco smoke toxins tested for were substantially reduced

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publichealth.yale.edu

Nicotine facilitates increased dopamine in the cortex similarly to observations in subcortical regions in that the drug binds high-affinity nAChRs on dopamine neurons that project from the VTA, but in this case toward the cortex, and binds low-affinity receptors on excitatory glutamatergic neurons projecting toward the prefrontal cortex (99, 100)

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