2 Methods 2.1 Literature search PubMed, Web of Science, China National Knowledge Infrastructure (CNKI) were searched, using keywords such as Chronic obstructive pulmonary disease, Mitochondrial dysfunction, Mitochondrial quality control, Mitophagy, Mitochondrial dynamics, Mitochondrial biogenesis, Therapeutic strategies to retrieve studies in ameliorating COPD by targeting mitochondria
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To investigate the underlying mechanisms, we performed subsequent in vivo and in vitro experiments
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It is an infection that causes damage not only to the teeth but also the soft tissues surrounding them