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Between 340 and 680 million kilograms of waste is generated every year, and while the amount of waste that is or isnt properly disposed of is not clear, smokers evidently struggle to adequately get rid of their butts (WHO, 2017)

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Thus, accumulation of -ketoglutarate upon CSE treatment might lead to enhanced PHD activation resulting in increased HIF-degradation at least under hypoxia, where hydroxylated HIF-1 was increased by CSE