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Extracellular glutathione S-transferase omega-1, a cytosolic enzyme that modulates the S-thiolation status of intracellular factors involved in the inflammatory response, and its polymorphisms have been associated with an increased risk to develop COPD and could have a biological and clinical significance in cystic fibrosis (115)
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IV administration delivers the compound directly into circulation, bypassing first-pass metabolismhigher efficacy, higher risk, higher regulatory scrutiny
Gastroenterology 150 , 194205 (2016)
Impaired mitochondrial oxidative phosphorylation limits the self-renewal of T cells exposed to persistent antigen
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