10.1104/pp.103.030940 Plant Physiol
NAD+, the mitochondrial side of recovery NAD+ is a different molecule for a different problem
SULT1A1 also takes part in transformation of hydroxymethyl polycyclic aromatic hydrocarbons, hydroxyderivatives of arylamines, allylic alcohols and heterocyclic amines to their reactive intermediates which are able to bind to nucleophilic structures such as DNA and consequently act as mutagens and carcinogens (Glatt et al., 2001)
By blocking NNMT, it shifts intracellular NAD+ and S-adenosylmethionine (SAM) levels, two cofactors tied to energy metabolism, redox balance, and gene regulation in laboratory models
These interactions play a pivotal role in modulating the activation state of cells comprising the BBB, as well as Ms and microglia, themselves