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They estimated that the PG exposure from one 50-to 70-mL puff would be from 430 to 603 mg/m 3 , and noted that These exposure concentrations were higher than the points of departure for airway irritation based on a human study (propylene glycol, mean concentration of 309 mg/m 3 ) and a rat study (glycerol, no-observed adverse effect level of 165 mg/m 3 ) (Kienhuis et al., 2015, p