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In lipopolysaccharide (LPS)-induced inflammatory injury in RAW264.7 macrophages of mice, solanesol enhances the transcriptional level of Nrf2 by activating Akt and p38 signaling pathways, which further upregulates the expression level and the activity of heme oxygenase-1 (HO-1), and improves the antioxidant capacity of cells

This finding was in agreement with a previous study that demonstrated the attenuation of A549 alveolar cellular growth secondary to cigarette exposure 9

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