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Psychosocial stress (e.g., giving subjects a demanding task and distracting them at the same time) caused an increase in the stress hormones epinephrine and cortisol, but the addition of a moderate amount of caffeine more than doubled the stress response.19 Importantly, the researchers found that habitual and light caffeine consumers had basically the same increase in stress hormones, proving that people do not develop a tolerance to the anxiety-producing effects of caffeine

Therefore, a reasonable speculation is the macrophage could induce ferroptotic cell death of epithelial cells which might further drive COPD

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