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and it should be discontinued in patients with an estimated GFR less than 30 mL per minute per 1.73 m 2.13,14 A Cochrane review pooling data from 347 trials revealed no cases of lactic acidosis in more than 70,000 patient-years of metformin use

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On the other hand, calls for treating obesity as a disease have led some states to mandate weight-loss medication coverage (e.g

These medications are provided in partnership with a Food and Drug Administration-regulated 503B compounding pharmacy, the company said

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