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This metabolic disease involves defects in insulin secretion and action, and is closely linked to obesity, genetic factors, and metabolic inflammation, and its complex pathologic mechanisms are driving the deepening of cutting-edge research in endocrine medicine

anyone with a physician-managed cardiovascular condition

doi:10.1097/RHU.0000000000001949 8

On the other hand, in a woman with estrogen excess despite having an optimal 2OH/4OH ratio if the 4-OH value is above range because of high levels of estrogen in the body, there is still concern for potential DNA damage from elevated 4-OH metabolites

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