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The susceptibility loci ATG16L1 directly affect the function of Paneth cells, which exhibit defects in the exocytosis of their granules (37) and affect, in the case of some specific mutations, their response to endoplasmic reticulum stress (38)

E-cigarettes should be prescribed on the NHS, says health body Public Health England says vaping is 95% less harmful than smoking and could save thousands of lives Electronic cigarettes should be made available on the NHS to help smokers quit, public health officials have announced

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